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Literature summary for 2.3.1.51 extracted from

  • Lu, B.; Jiang, Y.J.; Man, M.Q.; Brown, B.; Elias, P.M.; Feingold, K.R.
    Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis (2005), J. Lipid Res., 46, 2448-2457.
    View publication on PubMed
Search for more literature for 2.3.1.51

Activating Compound

Activating Compound Comment Organism Structure
additional information isozyme AGPAT2 and AGPAT5 expression increase in parallel with both an increase in enzyme activity and permeability barrier formation late in rat epidermal development, acute permeability barrier disruption, by tape-stripping, leads to rapidly increased expression of isozymes AGPAT 1, 2, and 3, reversible by occlusion Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Mus musculus the expression of AGPATs is linked to skin barrier requirements CoA + 1,2-diacyl-sn-glycerol 3-phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 isozymes AGPAT1,2,3, and 5
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Source Tissue

Source Tissue Comment Organism Textmining
epidermis isozyme AGPAT2 and AGPAT5 expression increase in parallel with both an increase in enzyme activity and permeability barrier formation late in rat epidermal development, acute permeability barrier disruption leads to rapidly increased expression of isozymes AGPAT 1, 2, and 3 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate the expression of AGPATs is linked to skin barrier requirements Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
1-acyl-sn-glycerol-3-phosphate acyltransferase
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 Mus musculus
AGPAT
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 Mus musculus