Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme can utilize the monomer form of long-chain acyl-CoA but it is inhibited by the micellar form of these substrates | Bos taurus | |
stearoyl-CoA | strongly inhibitory at 0.002 mM | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | 1-palmitoyl- and 1-oleoyl-sn-glycerol 3-phosphate are probably the substrates for the enzyme in vivo, since palmitic and oleic acids are the major fatty acid components at the sn-1 position of cow milk triacylglycerols. The specificity of the enzyme plays a major role in determining the fatty acid composition at the sn-2 position of cow milk triacylglycerols, though the influence of other factors such as the in vivo concentration of the acyl-CoAs and the specificities of the monoacylglycerol acyltransferases cannot be ruled out | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
Jersey cow | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary gland | lactating | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | the enzyme is active towards acyl-CoAs of chain length C-8 to C-18 | Bos taurus | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | - |
Bos taurus | CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate | - |
? | |
acyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate | - |
Bos taurus | CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate | - |
? | |
additional information | no acyl-donors are butyryl-CoA and hexanoyl-CoA | Bos taurus | ? | - |
? | |
additional information | the chain length specificity of the enzyme in decreasing order is as follows: C16, C14, C12, C10, C8 | Bos taurus | ? | - |
? | |
additional information | 1-palmitoyl- and 1-oleoyl-sn-glycerol 3-phosphate are probably the substrates for the enzyme in vivo, since palmitic and oleic acids are the major fatty acid components at the sn-1 position of cow milk triacylglycerols. The specificity of the enzyme plays a major role in determining the fatty acid composition at the sn-2 position of cow milk triacylglycerols, though the influence of other factors such as the in vivo concentration of the acyl-CoAs and the specificities of the monoacylglycerol acyltransferases cannot be ruled out | Bos taurus | ? | - |
? | |
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate | maximum activity is obtained with palmitoyl-CoA at a concentration of 0.002-0.003 mM | Bos taurus | CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |