Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | in quiescent cells | Homo sapiens | 5829 | - |
nucleus | nuclear association in proliferating cells | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | Homo sapiens | the enzyme catalyzes the initial and rate-limiting step in de novo sphingolipid synthesis. Potential role for overexpression of SPT in processes of cell metastasis | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | strong overexpression of both SPT subunits | Homo sapiens | - |
fibroblast | proliferating, neonatal, dermal | Homo sapiens | - |
leiomyosarcoma cell | strong overexpression of both SPT subunits | Homo sapiens | - |
ovary cancer cell | strong overexpression of both SPT subunits | Homo sapiens | - |
pancreatic cancer cell | strong overexpression of both SPT subunits | Homo sapiens | - |
sarcoma cell | strong overexpression of both SPT subunits | Homo sapiens | - |
thyroid cancer cell | strong overexpression of both SPT subunits | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | the enzyme catalyzes the initial and rate-limiting step in de novo sphingolipid synthesis. Potential role for overexpression of SPT in processes of cell metastasis | Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SPT | - |
Homo sapiens |