Literature summary for 2.3.1.50 extracted from

Van Echten-Deckert, G.; Zschoche, A.; Bar, T.; Schmidt, R.R.; Raths, A.; Heinemann, T.; Sandhoff, K.
cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons (1997), J. Biol. Chem., 272, 15825-15833.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cis-4-methylsphingosine	time- and concentration-dependent, causes drastic morphological changes of the cells in vivo	Mus musculus
cis-5-methylsphingosine	weak inhibition	Mus musculus
cis-sphingosine	weak inhibition	Mus musculus
trans-4-methylsphingosine	-	Mus musculus
trans-5-methylsphingosine	weak inhibition	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebellum	granule cells, neuronal cells	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoyl-CoA + L-serine	-	Mus musculus	CoA + 3-dehydro-D-sphinganine + CO2	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mus musculus

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Release 2023.1 (January 2023)