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Literature summary for 2.3.1.5 extracted from

  • Sim, E.; Sandy, J.; Evangelopoulos, D.; Fullam, E.; Bhakta, S.; Westwood, I.; Krylova, A.; Lack, N.; Noble, M.
    Arylamine N-acetyltransferases in mycobacteria (2008), Curr. Drug Metab., 9, 510-519.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
Mycobacterium smegmatis and Mycobacterium marinum Mycobacterium marinum
Mycobacterium smegmatis and Mycobacterium marinum Mycolicibacterium smegmatis

Protein Variants

Protein Variants Comment Organism
G207R mutation found in clinically isolated strains of Mycobacterium tuberculosis, resulting in a NAT enzyme with very poor activity Mycobacterium tuberculosis
additional information deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present Mycolicibacterium smegmatis
additional information deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present. NAT gene is essential for survival of Mycobacterium bovis within macrophage Mycobacterium tuberculosis variant bovis
additional information overexpression in Mycobacterium bovis results in a decreased susceptibility to isoniazid in the slow growing mycobacterium Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + isoniazid Mycolicibacterium smegmatis
-
CoA + N-acetylisoniazid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245
-
-
Mycobacterium avium
-
K-10, str. 104
-
Mycobacterium marinum
-
-
-
Mycobacterium sp. JLS
-
-
-
Mycobacterium sp. KMS
-
-
-
Mycobacterium sp. MCS
-
-
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis
-
CDC1551, Haarlem, F11, C, H73Rv
-
Mycobacterium tuberculosis variant bovis
-
-
-
Mycobacterium tuberculosis variant bovis
-
BCG Pasteur, AF2122/97
-
Mycobacterium tuberculosis variant bovis BCG
-
-
-
Mycobacterium ulcerans
-
Agy99
-
Mycobacterium ulcerans Agy99
-
Agy99
-
Mycolicibacterium gilvum
-
PYR-GCK
-
Mycolicibacterium gilvum PYR-GCK
-
PYR-GCK
-
Mycolicibacterium smegmatis O86309
-
-
Mycolicibacterium smegmatis O86309 mc2 155
-
Mycolicibacterium vanbaalenii
-
PYR-1
-
Mycolicibacterium vanbaalenii PYR-1
-
PYR-1
-
Rhodococcus
-
RHA1
-
Rhodococcus RHA1
-
RHA1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + isoniazid
-
Mycolicibacterium smegmatis CoA + N-acetylisoniazid
-
?
acetyl-CoA + isoniazid inactivation of the anti-tubercular drug isoniazid by acetyltransfer Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase
-
Mycobacterium avium
arylamine N-acetyltransferase
-
Mycobacterium tuberculosis
arylamine N-acetyltransferase
-
Mycobacterium tuberculosis variant bovis
arylamine N-acetyltransferase
-
Rhodococcus
arylamine N-acetyltransferase
-
Mycobacterium marinum
arylamine N-acetyltransferase
-
Mycolicibacterium vanbaalenii
arylamine N-acetyltransferase
-
Homo sapiens
arylamine N-acetyltransferase
-
Mycobacterium ulcerans
arylamine N-acetyltransferase
-
Mycobacterium sp. MCS
arylamine N-acetyltransferase
-
Mycobacterium sp. KMS
arylamine N-acetyltransferase
-
Mycobacterium sp. JLS
arylamine N-acetyltransferase
-
Mycolicibacterium gilvum
arylamine N-acetyltransferase
-
Mycobacterium tuberculosis variant bovis BCG
arylamine N-acetyltransferase
-
Mycolicibacterium smegmatis
NAT
-
Mycobacterium avium
NAT
-
Mycobacterium tuberculosis
NAT
-
Mycobacterium tuberculosis variant bovis
NAT
-
Rhodococcus
NAT
-
Mycobacterium marinum
NAT
-
Mycolicibacterium vanbaalenii
NAT
-
Homo sapiens
NAT
-
Mycobacterium ulcerans
NAT
-
Mycobacterium sp. MCS
NAT
-
Mycobacterium sp. KMS
NAT
-
Mycobacterium sp. JLS
NAT
-
Mycolicibacterium gilvum
NAT
-
Mycolicibacterium smegmatis
NAT2
-
Mycobacterium tuberculosis
NAT2
-
Mycobacterium marinum
NAT2
-
Homo sapiens
NAT2
-
Mycobacterium tuberculosis variant bovis BCG
NAT2
-
Mycolicibacterium smegmatis