Crystallization (Comment) | Organism |
---|---|
Mycobacterium smegmatis and Mycobacterium marinum | Mycobacterium marinum |
Mycobacterium smegmatis and Mycobacterium marinum | Mycolicibacterium smegmatis |
Protein Variants | Comment | Organism |
---|---|---|
G207R | mutation found in clinically isolated strains of Mycobacterium tuberculosis, resulting in a NAT enzyme with very poor activity | Mycobacterium tuberculosis |
additional information | deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present | Mycolicibacterium smegmatis |
additional information | deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present. NAT gene is essential for survival of Mycobacterium bovis within macrophage | Mycobacterium tuberculosis variant bovis |
additional information | overexpression in Mycobacterium bovis results in a decreased susceptibility to isoniazid in the slow growing mycobacterium | Mycolicibacterium smegmatis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + isoniazid | Mycolicibacterium smegmatis | - |
CoA + N-acetylisoniazid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11245 | - |
- |
Mycobacterium avium | - |
K-10, str. 104 | - |
Mycobacterium marinum | - |
- |
- |
Mycobacterium sp. JLS | - |
- |
- |
Mycobacterium sp. KMS | - |
- |
- |
Mycobacterium sp. MCS | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis | - |
CDC1551, Haarlem, F11, C, H73Rv | - |
Mycobacterium tuberculosis variant bovis | - |
- |
- |
Mycobacterium tuberculosis variant bovis | - |
BCG Pasteur, AF2122/97 | - |
Mycobacterium tuberculosis variant bovis BCG | - |
- |
- |
Mycobacterium ulcerans | - |
Agy99 | - |
Mycobacterium ulcerans Agy99 | - |
Agy99 | - |
Mycolicibacterium gilvum | - |
PYR-GCK | - |
Mycolicibacterium gilvum PYR-GCK | - |
PYR-GCK | - |
Mycolicibacterium smegmatis | O86309 | - |
- |
Mycolicibacterium smegmatis | O86309 | mc2 155 | - |
Mycolicibacterium vanbaalenii | - |
PYR-1 | - |
Mycolicibacterium vanbaalenii PYR-1 | - |
PYR-1 | - |
Rhodococcus | - |
RHA1 | - |
Rhodococcus RHA1 | - |
RHA1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + isoniazid | - |
Mycolicibacterium smegmatis | CoA + N-acetylisoniazid | - |
? | |
acetyl-CoA + isoniazid | inactivation of the anti-tubercular drug isoniazid by acetyltransfer | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase | - |
Mycobacterium avium |
arylamine N-acetyltransferase | - |
Mycobacterium tuberculosis |
arylamine N-acetyltransferase | - |
Mycobacterium tuberculosis variant bovis |
arylamine N-acetyltransferase | - |
Rhodococcus |
arylamine N-acetyltransferase | - |
Mycobacterium marinum |
arylamine N-acetyltransferase | - |
Mycolicibacterium vanbaalenii |
arylamine N-acetyltransferase | - |
Homo sapiens |
arylamine N-acetyltransferase | - |
Mycobacterium ulcerans |
arylamine N-acetyltransferase | - |
Mycobacterium sp. MCS |
arylamine N-acetyltransferase | - |
Mycobacterium sp. KMS |
arylamine N-acetyltransferase | - |
Mycobacterium sp. JLS |
arylamine N-acetyltransferase | - |
Mycolicibacterium gilvum |
arylamine N-acetyltransferase | - |
Mycobacterium tuberculosis variant bovis BCG |
arylamine N-acetyltransferase | - |
Mycolicibacterium smegmatis |
NAT | - |
Mycobacterium avium |
NAT | - |
Mycobacterium tuberculosis |
NAT | - |
Mycobacterium tuberculosis variant bovis |
NAT | - |
Rhodococcus |
NAT | - |
Mycobacterium marinum |
NAT | - |
Mycolicibacterium vanbaalenii |
NAT | - |
Homo sapiens |
NAT | - |
Mycobacterium ulcerans |
NAT | - |
Mycobacterium sp. MCS |
NAT | - |
Mycobacterium sp. KMS |
NAT | - |
Mycobacterium sp. JLS |
NAT | - |
Mycolicibacterium gilvum |
NAT | - |
Mycolicibacterium smegmatis |
NAT2 | - |
Mycobacterium tuberculosis |
NAT2 | - |
Mycobacterium marinum |
NAT2 | - |
Homo sapiens |
NAT2 | - |
Mycobacterium tuberculosis variant bovis BCG |
NAT2 | - |
Mycolicibacterium smegmatis |