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Literature summary for 2.3.1.5 extracted from

  • Weber, W.W.; King, C.M.
    N-Acetyltransferase and arylhydroxamic acid acyltransferase (1981), Methods Enzymol., 77, 272-280.
    View publication on PubMed
Search for more literature for 2.3.1.5

General Stability

General Stability Organism
dithiothreitol stabilizes Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Oryctolagus cuniculus
Mn2+
-
 Oryctolagus cuniculus
additional information no inhibition by CdCl2, arsenite, diisopropylfluorophosphate; no inhibition by paraoxon Oryctolagus cuniculus
N-ethylmaleimide
-
 Oryctolagus cuniculus
Ni2+
-
 Oryctolagus cuniculus
p-chloromercuribenzoate
-
 Oryctolagus cuniculus
Zn2+
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Oryctolagus cuniculus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
 1 * 33000, SDS-PAGE Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
no activity in Canis familiaris
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Oryctolagus cuniculus
-
additional information distribution in mammalian tissues Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.198
-
-
 Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
frozen, over a long-time range as ammonium sulfate precipitate Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene
-
 Oryctolagus cuniculus CoA + 2-acetylaminofluorene
-
 ?
acetyl-CoA + 4-aminobenzoic acid
-
 Oryctolagus cuniculus CoA + 4-acetylaminobenzoic acid
-
 ?
acetyl-CoA + 4-aminosalicylic acid
-
 Oryctolagus cuniculus CoA + 4-acetylamino-2-hydroxybenzoate
-
 ?
acetyl-CoA + aniline
-
 Oryctolagus cuniculus CoA + acetanilide
-
 ?
acetyl-CoA + benzidine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + diaminodiphenylsulfone
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + histamine
-
 Oryctolagus cuniculus CoA + N-acetylhistamine
-
 ?
acetyl-CoA + hydralazine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + isoniazide
-
 Oryctolagus cuniculus CoA + acetylniazide
-
 ?
acetyl-CoA + methyl bis-2-chloroaniline
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + naphthylamine
-
 Oryctolagus cuniculus CoA + N-acetylnaphthylamine
-
 ?
acetyl-CoA + p-phenetidine
-
 Oryctolagus cuniculus CoA + N-(4-ethoxyphenyl)-acetamide
-
 ?
acetyl-CoA + p-tyramine
-
 Oryctolagus cuniculus CoA + N-acetyl-p-tyramine
-
 ?
acetyl-CoA + phenelzine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + procainamide
-
 Oryctolagus cuniculus CoA + N-acetylprocainamide
-
 ?
acetyl-CoA + serotonin
-
 Oryctolagus cuniculus CoA + N-acetylserotonin
-
 ?
acetyl-CoA + sulfadiazine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + sulfamethazine
-
 Oryctolagus cuniculus CoA + N-4-acetylsulfamethazine
-
 ?
acetyl-CoA + sulfanilamide
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + sulfapyridine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
acetyl-CoA + thiazolsulfone
-
 Oryctolagus cuniculus CoA + ?
-
 ?
additional information the enzyme exhibits arylhydroxamic acid N,O-acetyltransferase activity Oryctolagus cuniculus ?
-
 ?
additional information N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 33000, SDS-PAGE Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 9 isoniazide, sulfanilamide Oryctolagus cuniculus
5.6
-
 sulfamethazine, 2 optima Oryctolagus cuniculus
5.7
-
 sulfadiazine Oryctolagus cuniculus
7.2
-
 sulfamethazine, 2 optima Oryctolagus cuniculus