Protein Variants | Comment | Organism |
---|---|---|
additional information | MOF levels are strongly diminished after incubating cells for 4 days with interfering RNAs directed against MOF transcript, and are undetectable after 5.5 days | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Drosophila melanogaster | acetylation of Lys9, Lys14, Lys18, Lys23, Lys27, Lys36, and Lys37 | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | Drosophila melanogaster | acetylation of Lys5, Lys8, Lys12, and Lys16 | CoA + acetylhistone H4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Kc cell | - |
Drosophila melanogaster | - |
S2 cell | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation of Lys9, Lys14, Lys18, Lys23, Lys27, Lys36, and Lys37 | Drosophila melanogaster | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | acetylation of Lys5, Lys8, Lys12, and Lys16 | Drosophila melanogaster | CoA + acetylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gcn5 | - |
Drosophila melanogaster |
KAT6 | - |
Drosophila melanogaster |
NAA10 | - |
Drosophila melanogaster |
RPD3 | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | aberrant histone acetylation contributes to disease | Drosophila melanogaster |
additional information | development of a quantitative proteomic strategy to generate a comprehensive catalog of combinatorial histone acetylation and methylation motifs in Drosophila cells, acetylation patterns and their genesis by integrated enzyme activities, e.g. via enzymes MOF, RPD3, KAT6, NAA10, and GCN5, overview | Drosophila melanogaster |
physiological function | regulation of histone acetylation is fundamental to the utilization of eukaryotic genomes in chromatin. H4K16 acetylation is thought to affect the basic properties of the chromatin fiber. Male cells display twice the amount of H4K16 acetylation but reduced levels of several other acetylation motifs including H4K5, H4K12, and H3K14 acetylation as compared to female cells due to acetyltransferase MOF. Drosophila's histone acetylation system includes (1) the extensively studied model KATs (GCN5/PCAF, CBP/P300, MOF, HAT1, and TIP60), (2) less well characterized KATs (KAT6 [MOZ/MORF], HBO1, ELP3, TAF1, and ATAC2), (3) a mostly uncharacterized class of GCN5-related KATs (NAT6, NAT9, and NAT10), (4) N-terminal acetyltransferases suggested to also acetylate internal lysines (NAA10, NAA20, NAA30, NAA40, NAA50, and NAA60), (5) putative acetyltransferases with no recognizable direct homologue in non-Drosophilid species (CG5783 and CG12560), (6) the acetyltransferase ECO, and (7) a bifunctional enzyme containing a O-GlcNAcase activity and potentially a KAT activity (MGEA5, also known as NCOAT or OGA) | Drosophila melanogaster |