Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anacardic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p300 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | megakaryoblastic leukemia 1 (MKL1, also named MRTF-A), a myocardin-related transcription factor, and histone acetyltransferase p300 can synergistically augment the expression of atechol-O-methyltransferase COMT gene, increase the metabolic rate of estrogen, and thus reduce the proliferation of MCF-7 breast cancer cells stimulated by estrogen. Transactivation of COMT induced by MKL1 and p300 is mediated via MKL1-SRF-CArG-box signal transduction | Homo sapiens |
physiological function | acetylation of histones in the promoter region is a key step in transcription initiation. histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene. Histone acetyltransferase p300 is recruited to the promoters of certain cardiac and smooth muscle specific genes to enhance the transactivation activity of myocardin, which is a master regulator in cardiovascular differentiation and development | Homo sapiens |