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Literature summary for 2.3.1.48 extracted from

  • Liu, Z.; Luo, X.; Liu, L.; Zhao, W.; Guo, S.; Guo, Y.; Wang, N.; He, H.; Liao, X.; Ma, W.; Zhou, H.; Zhang, T.
    Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene (2013), Acta Biochim. Biophys. Sin. (Shanghai), 45, 1002-1010.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
anacardic acid
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
p300
-
Homo sapiens

General Information

General Information Comment Organism
metabolism megakaryoblastic leukemia 1 (MKL1, also named MRTF-A), a myocardin-related transcription factor, and histone acetyltransferase p300 can synergistically augment the expression of atechol-O-methyltransferase COMT gene, increase the metabolic rate of estrogen, and thus reduce the proliferation of MCF-7 breast cancer cells stimulated by estrogen. Transactivation of COMT induced by MKL1 and p300 is mediated via MKL1-SRF-CArG-box signal transduction Homo sapiens
physiological function acetylation of histones in the promoter region is a key step in transcription initiation. histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene. Histone acetyltransferase p300 is recruited to the promoters of certain cardiac and smooth muscle specific genes to enhance the transactivation activity of myocardin, which is a master regulator in cardiovascular differentiation and development Homo sapiens