Literature summary for 2.3.1.48 extracted from

Miao, J.; Fan, Q.; Cui, L.; Li, X.; Wang, H.; Ning, G.; Reese, J.C.; Cui, L.
The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum (2010), Mol. Microbiol., 78, 883-902.

Search for more literature for 2.3.1.48

Protein Variants

Protein Variants	Comment	Organism
additional information	recombinant protein expressed in prokaryotes and insect cells does not show activity, recombinant protein purified from the parasites exhibits a predilection to acetylate histone H4 in vitro at K5, K8, K12 and K16	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	and nucleus	Plasmodium falciparum	5737	-
nucleus	and cytoplasm	Plasmodium falciparum	5634	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8III2	gene PF11_0192, putative	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + histone H4	-	Plasmodium falciparum	CoA + acetylhistone H4	acetylates histone H4 in vitro at K5, K8, K12 and K16	?
additional information	protein participates in var gene activation	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
PF11_0192	-	Plasmodium falciparum

Expression

Organism	Comment	Expression
Plasmodium falciparum	gene PF11_0192 is expressed in erythrocytic stages as a long and a short version	additional information

General Information

General Information	Comment	Organism
physiological function	enzyme is essential for asexual intraerythrocytic growth. Overexpression of the long, active or a truncated, non-active version of the protein by stable integration of the expression cassette in the parasite genome results in changes of H4 acetylation and cell cycle progression. Overexpressing parasites shows changes in sensitivity to DNA-damaging agents	Plasmodium falciparum

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Release 2023.1 (January 2023)