Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Toxoplasma gondii | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H3 peptide | - |
Toxoplasma gondii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lysine acetyltransferase | - |
Toxoplasma gondii |
TgMYST-B | - |
Toxoplasma gondii |
General Information | Comment | Organism |
---|---|---|
malfunction | expression of mutant TgMYST-B produces no growth defect and fails to protect against DNA damage | Toxoplasma gondii |
malfunction | overexpression of recombinant, tagged TgMYST-B reduces growth rate in vitro and confers protection from a DNA-alkylating agent. Cells overexpressing TgMYST-B have increased levels of ataxia telangiectasia mutated (ATM) kinase and phosphorylated H2AX and that TgMYST-B localizes to the ATM kinase gene. Pharmacological inhibitors of ATM kinase or KATs reverse the slow growth phenotype seen in parasites overexpressing TgMYST-B | Toxoplasma gondii |