Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
expressed in Escherichia coli | Saccharomyces cerevisiae |
Crystallization (Comment) | Organism |
---|---|
the X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins | Homo sapiens |
the X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
K262Q | mutant does support growth of yeast cells | Saccharomyces cerevisiae |
K262R | mutant does not support growth of yeast cells, mutant is catalytically inactive | Saccharomyces cerevisiae |
K274R | mutant is catalytically inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | Q08649 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | acetyltransferase activity requires active site lysine autoacetylation at a conserved lysine K262 | Homo sapiens |
additional information | acetyltransferase activity requires active site lysine autoacetylation at a conserved lysine K262 | Saccharomyces cerevisiae |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H4 peptide + acetyl-CoA | - |
Homo sapiens | ? | - |
? | |
H4 peptide + acetyl-CoA | - |
Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Esa1 | - |
Saccharomyces cerevisiae |
histone acetyltransferase | - |
Saccharomyces cerevisiae |
hMOF | - |
Homo sapiens |
MYST protein lysine acetyltransferase | - |
Homo sapiens |
MYST protein lysine acetyltransferase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
7.6 | - |
assay at | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | MYST protein acetyltransferase activity requires active site lysine autoacetylation | Homo sapiens |
physiological function | MYST protein acetyltransferase activity requires active site lysine autoacetylation | Saccharomyces cerevisiae |