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Literature summary for 2.3.1.48 extracted from

  • Kim, M.K.; Shin, J.M.; Eun, H.C.; Chung, J.H.
    The role of p300 histone acetyltransferase in UV-induced histone modifications and MMP-1 gene transcription (2009), PLoS ONE, 4, e4864.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information overexpression of p300 increases the basal and UV-induced matrix metalloproteinase MMP-1 promoter activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anacardic acid a p300HAT inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Homo sapiens
-
 CoA + acetylhistone H3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary dermal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3
-
 Homo sapiens CoA + acetylhistone H3
-
 ?

Synonyms

Synonyms Comment Organism
p300 histone acetyltransferase
-
 Homo sapiens
p300HAT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens down-regulation of p300 by siRNA prevents UV-induced matrix metalloproteinase MMP-1 expression and inhibits UV-enhanced phosphorylation of H2AX, p53 level, and acetyl-H3 down
Homo sapiens UV irradiation of cultured human dermal fibroblasts induces matrix metalloproteinase MMP-1 expression and increases the level of phosphorylation of H2AX, p53 and the acetylation of histone H3 up