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Literature summary for 2.3.1.48 extracted from
- Structure and function of MYST1 histone acetyltransferase in the interactome of animal cells (2008), Biochemistry (Moscow), 73, 839-852.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| MYST1, sequence comparison, phylogenetic tree | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | Drosophila melanogaster | acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B | CoA + acetylhistone H4 | - |
? |  |
| acetyl-CoA + histone H4 | Homo sapiens | MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific. Acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B. All human autosomes are susceptible to histone H4 acetylation by Lys16 residue and acetyltransferase MYST1 | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + p53 | Homo sapiens | p53 protein-acetylation of the Lys120 residue | CoA + acetyl-p53 | - |
? | |
| additional information | Drosophila melanogaster | MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. Interactions between MSL1 and MYST1 within the MSL complex in Drosophila melanogaster, the compensasome includes proteins MSL1, MSL2, MSL3, MLE, MOF, a histone acetyltransferase homologous to MYST1, JIL1, and two non-coding RNA: roX1 and roX2, structure and function of the compensasome, detailed overview. Cell interactome fragments including protein homologs of hampin and MYST1, overview | ? | - |
? | |
| additional information | Homo sapiens | MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. MYST1 interacts with WDR5. Cell interactome fragments including protein homologs of hampin and MYST1, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | Q9H7Z6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H2A | - |
Homo sapiens | CoA + acetylhistone H2A | - |
? | |
| acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
| acetyl-CoA + histone H4 | acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B | Drosophila melanogaster | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific. Acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B. All human autosomes are susceptible to histone H4 acetylation by Lys16 residue and acetyltransferase MYST1 | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | acetylation at Lys16 by MYST1 | Drosophila melanogaster | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | acetylation at Lys16 by MYST1 | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + p53 | p53 protein-acetylation of the Lys120 residue | Homo sapiens | CoA + acetyl-p53 | - |
? | |
| acetyl-CoA + p53 | p53 protein-acetylation of the Lys120 residue is carried out by acetyltransferases MYST1 and TIP60 to approximately equal extent | Homo sapiens | CoA + acetyl-p53 | - |
? | |
| additional information | MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. Interactions between MSL1 and MYST1 within the MSL complex in Drosophila melanogaster, the compensasome includes proteins MSL1, MSL2, MSL3, MLE, MOF, a histone acetyltransferase homologous to MYST1, JIL1, and two non-coding RNA: roX1 and roX2, structure and function of the compensasome, detailed overview. Cell interactome fragments including protein homologs of hampin and MYST1, overview | Drosophila melanogaster | ? | - |
? | |
| additional information | MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. MYST1 interacts with WDR5. Cell interactome fragments including protein homologs of hampin and MYST1, overview | Homo sapiens | ? | - |
? | |
| additional information | MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone (H4 K16) acetyltransferase | - |
Drosophila melanogaster |
| histone (H4 K16) acetyltransferase | - |
Homo sapiens |
| Mof | - |
Homo sapiens |
| MYST1 | - |
Drosophila melanogaster |
| MYST1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Drosophila melanogaster | |
| acetyl-CoA | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | downregulation by RNA interference decreases the MYST1 content in human cells and results in lowered Lys16 acetylation in histone H4 | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disturbance of normal acetylation of K16 in histone H4 together with trimethylation of Lys20 in histone H4 is associated with early stages of tumor development | Homo sapiens |
| physiological function | MYST1 plays a role in tumor suppression mechanisms, functional composition and mechanisms of MYST1-containing complexes, overviewS | Drosophila melanogaster |
| physiological function | MYST1 plays a role in tumor suppression mechanisms, functional composition and mechanisms of MYST1-containing complexes, overviewS | Homo sapiens |
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