Literature summary for 2.3.1.48 extracted from

Lee, Y.H.; Hong, S.W.; Jun, W.; Cho, H.Y.; Kim, H.C.; Jung, M.G.; Wong, J.; Kim, H.I.; Kim, C.H.; Yoon, H.G.
Anti-histone acetyltransferase activity from allspice extracts inhibits androgen receptor-dependent prostate cancer cell growth (2007), Biosci. Biotechnol. Biochem., 71, 2712-2719.

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Application

Application	Comment	Organism
medicine	allspice hot water extract reduces androgen receptor and histone acetylation and leads to decreased transcription of androgen receptor target genes, resulting in inhibition of prostate cancer cell growth	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
allspice hot water extract	leads to a potent anti-HAT activity since the allspice hot water extract possesses a strong inhibitory effect on p300 and CBP (40% at 0.1 ng/ml). Chromatin immunoprecipitation indicates that the acetylation of histone H3 in the PSA and B2M promoter regions was also repressed	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
prostate cancer cell line	DU145	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HAT	-	Homo sapiens
histone acetyltransferase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)