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Literature summary for 2.3.1.48 extracted from

  • Gong, J.; Zhu, J.; Goodman, O.B.; Pestell, R.G.; Schlegel, P.N.; Nanus, D.M.; Shen, R.
    Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells (2006), Oncogene, 25, 2011-2021.
    View publication on PubMed
Search for more literature for 2.3.1.48

Activating Compound

Activating Compound Comment Organism Structure
additional information bombesin induces p300 expression 2fold, as part of the Src and PKCdelta pathways, a neutral endopeptidase, which degrades bombesin, or bombesin receptor antagonists, or p300 siRNA block bombesin-induced p300 HAT activity, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androgen receptor + acetyl-CoA Homo sapiens receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview acetylated androgen receptor + CoA
-
 ?
additional information Homo sapiens androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C4-2 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activation of p300 HAT activity and acetylation of the AR by bombesin in PC cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androgen receptor + acetyl-CoA receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview Homo sapiens acetylated androgen receptor + CoA
-
 ?
androgen receptor + acetyl-CoA the KLKK motif of androgen receptor protein is both necessary and sufficient for acetylation by p300 in the presence of 100 nM dihydrotestosterone Homo sapiens acetylated androgen receptor + CoA
-
 ?
additional information androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Homo sapiens
p300
-
 Homo sapiens