Cloned (Comment) | Organism |
---|---|
gene dGN5, genetic crosses and phenotype analysis, overview, determination of genetic interaction of dGcn5 and dAda2a | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
E355stop | site-directed mutagenesis of the Gn5 gene, inactive mutant, the loss of either dGcn5 or dAda2a function results in similar chromosome structural and developmental defects, in dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected, overview | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | Drosophila melanogaster | acetylation of Lys9, and Lys14 | acetyl-histone H3 + CoA | - |
? | |
histone H4 + acetyl-CoA | Drosophila melanogaster | acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation | acetyl-histone H4 + CoA | - |
? | |
additional information | Drosophila melanogaster | the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | acetylation of Lys9, and Lys14 | Drosophila melanogaster | acetyl-histone H3 + CoA | - |
? | |
histone H4 + acetyl-CoA | acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation | Drosophila melanogaster | acetyl-histone H4 + CoA | - |
? | |
histone H4 + acetyl-CoA | acetylation of Lys5, Lys8, and Lys12 | Drosophila melanogaster | acetyl-histone H4 + CoA | - |
? | |
additional information | the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gcn5 | - |
Drosophila melanogaster |
HAT | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Drosophila melanogaster |