Literature summary for 2.3.1.48 extracted from

Mantelingu, K.; Kishore, A.H.; Balasubramanyam, K.; Kumar, G.V.; Altaf, M.; Swamy, S.N.; Selvi, R.; Das, C.; Narayana, C.; Rangappa, K.S.; Kundu, T.K.
Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy (2007), J. Phys. Chem. B, 111, 4527-4534.

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Activating Compound

Activating Compound	Comment	Organism	Structure
2-chloro-4-trifluoromethyl benzamide	activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview	Homo sapiens
4-chloro-2-trifluoromethyl benzamide	activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview	Homo sapiens
additional information	no activation by 3-chloro-2-trifluoromethyl benzamide and 2-chloro-3-trifluoromethyl benzamide	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of His6-tagged enzyme in Spodoptora frugiperda Sf21 cell using the baculovirus infection system	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
histone + acetyl-CoA	Homo sapiens	-	acetyl-histone + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
histone + acetyl-CoA	-	Homo sapiens	acetyl-histone + CoA	-	?
histone + acetyl-CoA	histones from the Hela cell core	Homo sapiens	acetyl-histone + CoA	-	?

Synonyms

Synonyms	Comment	Organism
HAT	-	Homo sapiens
p300 HAT	-	Homo sapiens
p300 histone acetyltransferase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Homo sapiens

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Release 2023.1 (January 2023)