Literature summary for 2.3.1.48 extracted from

Mai, A.; Rotili, D.; Tarantino, D.; Ornaghi, P.; Tosi, F.; Vicidomini, C.; Sbardella, G.; Nebbioso, A.; Miceli, M.; Altucci, L.; Filetici, P.
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties (2006), J. Med. Chem., 49, 6897-6907.

Inhibitors

Inhibitors	Comment	Organism
3-quinolinecarboxylic acid ethyl ester	effects in vivo, overview	Homo sapiens
3-quinolinecarboxylic acid ethyl ester	effects in vivo, inhibitory effect on the transcription is not fully GCN5-specific, overview	Saccharomyces cerevisiae
4-hydroxy-2-pentylquinoline-3-carboxylate	effects in vivo, overview, in vitro clear reduction of the acetylation extents of both histone H3 and alpha-tubulin at 0.1 mM	Homo sapiens
4-hydroxy-2-pentylquinoline-3-carboxylic acid	-	Saccharomyces cerevisiae
anacardic acid	-	Homo sapiens
anacardic acid	-	Saccharomyces cerevisiae
curcumin	-	Homo sapiens
curcumin	-	Saccharomyces cerevisiae
ethyl 2-methylquinoline-3-carboxylate	effects in vivo, overview	Homo sapiens
ethyl 2-methylquinoline-3-carboxylate	effects in vivo, inhibitory effect on the transcription is fully GCN5-specific, overview	Saccharomyces cerevisiae
garcinol	-	Homo sapiens
garcinol	-	Saccharomyces cerevisiae
H3-CoA-20	-	Homo sapiens
H3-CoA-20	-	Saccharomyces cerevisiae
isothiazolone	-	Homo sapiens
isothiazolone	-	Saccharomyces cerevisiae
Lys-CoA	-	Homo sapiens
Lys-CoA	-	Saccharomyces cerevisiae
MB-3	-	Homo sapiens
MB-3	-	Saccharomyces cerevisiae
additional information	screening for small molecule inhibitors reducing the cell growth, overview	Homo sapiens
additional information	screening for small molecule inhibitors reducing the cell growth, overview	Saccharomyces cerevisiae

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
histone H3 + acetyl-CoA	Homo sapiens	-	acetyl-histone H3 + CoA	-	?
histone H3 + acetyl-CoA	Saccharomyces cerevisiae	-	acetyl-histone H3 + CoA	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Saccharomyces cerevisiae	-	several strains	-

Source Tissue	Comment	Organism	Textmining
U-937 cell	leukemia cell line	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
alpha-tubulin + acetyl-CoA	-	Homo sapiens	acetyl-alpha-tubulin + CoA	-	?
alpha-tubulin + acetyl-CoA	-	Saccharomyces cerevisiae	acetyl-alpha-tubulin + CoA	-	?
histone H3 + acetyl-CoA	-	Homo sapiens	acetyl-histone H3 + CoA	-	?
histone H3 + acetyl-CoA	-	Saccharomyces cerevisiae	acetyl-histone H3 + CoA	-	?
histone H3 tail peptide + acetyl-CoA	-	Saccharomyces cerevisiae	acetyl-histone H3 tail peptide + CoA	-	?

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Homo sapiens
acetyl-CoA	-	Saccharomyces cerevisiae