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Literature summary for 2.3.1.48 extracted from
- Tip60 acetyltransferase activity is controlled by phosphorylation (2003), J. Biol. Chem., 278, 4713-4718.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Tip60 plays a role in the control of cell-related events | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of Tip60 modulates its histone acetyltransferase activity. One of the phosphorylated serines, Ser90, is within a consensus cyclin B/Cdc2 site. Ser90 is specifically phosphorylated in vitro by the cyclin B/Cdc2 complex. The phosphorylation of Tip90 is enhanced after drug-induced arrest of cells in G2/M | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Tip60 plays a role in the control of cell-related events | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone acetyltransferase Tip60 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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