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Literature summary for 2.3.1.47 extracted from

  • Izumi, Y.; Sato, K.; Tani, Y.; Ogata, K.
    Distribution of 7-keto-8-aminopelargonic acid synthetase in bacteria and the control mechanism of the enzyme activity (1973), Agric. Biol. Chem., 37, 1335-1340.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
biotin stimulates Kocuria rosea
biotin stimulates Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
biotin
-
Bacillus subtilis
biotin
-
Lysinibacillus sphaericus
D-alanine
-
Lysinibacillus sphaericus
D-alanine
-
Pseudomonas fluorescens
D-histidine
-
Lysinibacillus sphaericus
D/L-histidine
-
Alcaligenes faecalis
D/L-histidine
-
Bacillus subtilis
D/L-histidine
-
Citrobacter freundii
D/L-histidine
-
Enterobacter cloacae
D/L-histidine
-
Erwinia aroidea
D/L-histidine
-
Escherichia coli
D/L-histidine
-
Klebsiella aerogenes
D/L-histidine
-
Kocuria rosea
D/L-histidine
-
Lysinibacillus sphaericus
D/L-histidine
-
Pseudomonas fluorescens
glycine
-
Lysinibacillus sphaericus
glycine
-
Pseudomonas fluorescens
L-cysteine
-
Escherichia coli
L-cysteine
-
Lysinibacillus sphaericus
L-cysteine
-
Pseudomonas fluorescens
L-histidine
-
Lysinibacillus sphaericus
L-serine
-
Lysinibacillus sphaericus
L-serine
-
Pseudomonas fluorescens
pyridoxal 5'-phosphate high concentrations Lysinibacillus sphaericus
Pyruvic acid
-
Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-carboxyhexanoyl-CoA + L-alanine Alcaligenes faecalis i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Bacillus subtilis i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Escherichia coli i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Enterobacter cloacae i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Lysinibacillus sphaericus i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Kocuria rosea i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Pseudomonas fluorescens i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Klebsiella aerogenes i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Citrobacter freundii i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Erwinia aroidea i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Alcaligenes faecalis reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Bacillus subtilis reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Escherichia coli reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Enterobacter cloacae reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Lysinibacillus sphaericus reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Kocuria rosea reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Pseudomonas fluorescens reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Klebsiella aerogenes reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Citrobacter freundii reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine Erwinia aroidea reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?

Organism

Organism UniProt Comment Textmining
Alcaligenes faecalis
-
-
-
Bacillus subtilis
-
-
-
Citrobacter freundii
-
-
-
Enterobacter cloacae
-
-
-
Erwinia aroidea
-
-
-
Escherichia coli
-
-
-
Klebsiella aerogenes
-
-
-
Kocuria rosea
-
-
-
Lysinibacillus sphaericus
-
-
-
Pseudomonas fluorescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Pseudomonas fluorescens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
crude cell-extracts from various organism Alcaligenes faecalis
additional information
-
crude cell-extracts from various organism Bacillus subtilis
additional information
-
crude cell-extracts from various organism Escherichia coli
additional information
-
crude cell-extracts from various organism Enterobacter cloacae
additional information
-
crude cell-extracts from various organism Lysinibacillus sphaericus
additional information
-
crude cell-extracts from various organism Kocuria rosea
additional information
-
crude cell-extracts from various organism Pseudomonas fluorescens
additional information
-
crude cell-extracts from various organism Klebsiella aerogenes
additional information
-
crude cell-extracts from various organism Citrobacter freundii
additional information
-
crude cell-extracts from various organism Erwinia aroidea
0.00016
-
-
Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Alcaligenes faecalis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Bacillus subtilis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Escherichia coli 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Enterobacter cloacae 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Lysinibacillus sphaericus 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Kocuria rosea 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Pseudomonas fluorescens 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Klebsiella aerogenes 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Citrobacter freundii 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Erwinia aroidea 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine L-cysteine cannot replace L-alanine Lysinibacillus sphaericus 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine L-cysteine cannot replace L-alanine Kocuria rosea 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine L-cysteine cannot replace L-alanine Pseudomonas fluorescens 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Alcaligenes faecalis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Bacillus subtilis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Escherichia coli 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Enterobacter cloacae 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Lysinibacillus sphaericus 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Kocuria rosea 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Pseudomonas fluorescens 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Klebsiella aerogenes 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Citrobacter freundii 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?
6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Erwinia aroidea 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ?

Synonyms

Synonyms Comment Organism
KAPA synthetase
-
Alcaligenes faecalis
KAPA synthetase
-
Bacillus subtilis
KAPA synthetase
-
Escherichia coli
KAPA synthetase
-
Enterobacter cloacae
KAPA synthetase
-
Lysinibacillus sphaericus
KAPA synthetase
-
Kocuria rosea
KAPA synthetase
-
Pseudomonas fluorescens
KAPA synthetase
-
Klebsiella aerogenes
KAPA synthetase
-
Citrobacter freundii
KAPA synthetase
-
Erwinia aroidea

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Alcaligenes faecalis
pyridoxal 5'-phosphate
-
Bacillus subtilis
pyridoxal 5'-phosphate
-
Escherichia coli
pyridoxal 5'-phosphate
-
Enterobacter cloacae
pyridoxal 5'-phosphate
-
Kocuria rosea
pyridoxal 5'-phosphate
-
Pseudomonas fluorescens
pyridoxal 5'-phosphate
-
Klebsiella aerogenes
pyridoxal 5'-phosphate
-
Citrobacter freundii
pyridoxal 5'-phosphate
-
Erwinia aroidea
pyridoxal 5'-phosphate dependent on Lysinibacillus sphaericus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.99
-
L-cysteine
-
Lysinibacillus sphaericus
1.24
-
D-alanine
-
Lysinibacillus sphaericus
1.5
-
L-serine
-
Lysinibacillus sphaericus
3.33
-
glycine
-
Lysinibacillus sphaericus
3.75
-
D-histidine
-
Lysinibacillus sphaericus
5.6
-
L-histidine
-
Lysinibacillus sphaericus