General Stability | Organism |
---|---|
lyophilisation causes loss of 20-30% activity, storage in lyophilized stage leads to additional loss of 60% activity | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | inhibition of membrane-bound enzyme | Bos taurus | |
iodoacetate | - |
Bos taurus | |
additional information | no inhibition by MgCl2, CaCl2, MnCl2 | Bos taurus | |
p-chloromercuribenzoate | - |
Bos taurus | |
Triton X-100 | no inhibition | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
acetyl-CoA | cytosolic enzyme | Bos taurus | |
0.12 | - |
acetyl-CoA | membrane-bound enzyme | Bos taurus | |
0.39 | - |
N-glycolylneuraminate | cytosolic enzyme | Bos taurus | |
0.5 | - |
N-acetylneuraminate | cytosolic enzyme | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
microsome | - |
Equus caballus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + sialic acid | Bos taurus | - |
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + sialic acid | Equus caballus | - |
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Equus caballus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
submandibular gland | - |
Bos taurus | - |
submandibular gland | - |
Equus caballus | - |
Storage Stability | Organism |
---|---|
0°C, 16 days, 55% loss of activity, membrane-bound enzyme | Bos taurus |
frozen enzyme is stable for at least 6 months | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + N-acetylneuraminate | - |
Equus caballus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + N-acetylneuraminate | the membrane-bound enzyme acts on endogenous, glycoprotein-bound N-acetyl- and N-glycolylneuraminic acids, the soluble enzyme acts on exogenous non-glycosidically bound N-acetyl- and N-glycolylneuraminic acids | Bos taurus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + N-glycolylneuraminate | - |
Bos taurus | ? | - |
? | |
acetyl-CoA + sialic acid | - |
Bos taurus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + sialic acid | - |
Equus caballus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Bos taurus |
37 | - |
- |
Equus caballus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.56 | - |
CoA | - |
Bos taurus |