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Literature summary for 2.3.1.43 extracted from

  • Pahl, M.V.; Ni, Z.; Sepassi, L.; Moradi, H.; Vaziri, N.D.
    Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD) (2009), Nephrol. Dial. Transplant., 24, 2541-2546.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information reduced LCAT expression can cause reduction of plasma HDL cholesterol concentration, impaired HDL maturation, altered HDL composition and increased plasma concentration of lipid-poor pre-beta HDL particles, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
liver enzyme expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
LCAT
-
 Homo sapiens
lecithin:cholesterol acyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction LCAT deficiency is involved in the end-stage renal insufficiency with elevated plasma triglyceride concentration, reduced and plasma HDL cholesterol, apolipoprotein A-1 and LCAT concentrations, whereas plasma phospholipid transfer protein and cholesteryl ester transfer protein concentrations and activities are unchanged in the patients Homo sapiens
metabolism LCAT catalyzes esterification of free cholesterol on the surface of HDL and is involved in HDL metabolism regulation Homo sapiens