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Literature summary for 2.3.1.43 extracted from

  • Amar, M.J.; Shamburek, R.D.; Vaisman, B.; Knapper, C.L.; Foger, B.; Hoyt, R.F.; Santamarina-Fojo, S.; Brewer, H.B.; Remaley, A.T.
    Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein (2009), Metab. Clin. Exp., 58, 568-575.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I kinetic analysis of radioiodinated ApoA-I associated with HDL and radioiodinated ApoB on LDL, mechanism for the effect of LCAT on lipid and lipoprotein changes, overview Homo sapiens

Application

Application Comment Organism
drug development LCAT is a potential drug target for reducing atherosclerosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of LCAT in male nonhuman primate squirrel monkeys, Saimiri sciureus, using an adenoviral vector affects the lipoprotein metabolism, leading to an antiatherogenic lipoprotein profile by increasing HDL cholesterol and lowering ApoB, overview. Increased LCAT activity is also associated with a change in the size of HDL Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted from liver to blood plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol cholesteryl ester + lysophosphatidylcholine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
liver expression of LCAT Homo sapiens
-
additional information most LCAT activity is found on high-density lipoprotein, HDL, but approximately 30% is also localized on apolipoprotein B-containing lipoproteins Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + cholesterol
-
Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
?
phosphatidylcholine + cholesterol LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
?

Synonyms

Synonyms Comment Organism
LCAT
-
Homo sapiens
lecithin-cholesterol acyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism LCAT is a key enzyme in high-density lipoprotein, HDL, metabolism Homo sapiens