Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | required as cofactor | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deleterious LCAT mutants show low HDL-cholesterol levels | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | blood plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | Homo sapiens | LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to free cholesterol with apolipoprotein A-I as cofactor | cholesteryl ester + lysophosphatidylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | LCAT levels are higher in females compared to males | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to free cholesterol with apolipoprotein A-I as cofactor | Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin:cholesterol acyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | a high LCAT level is associated with an increased coronary artery disease risk in women | Homo sapiens |
physiological function | LCAT plays a role in HDL maturation | Homo sapiens |