Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | - |
Oryctolagus cuniculus |
Cloned (Comment) | Organism |
---|---|
overexpression of LCAT in rabbit hepatocytes | Oryctolagus cuniculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | hepatocyte-directed adenoviral gene transfer of LCAT or apolipoprotein A-I to LDLr+/- rabbits with 0.15% cholesterol-diet-induced hyperlipidemia increases the HDL cholesterol in these rabbits, intimal lesions in organs of the LDL+/- heterozygous rabbits, overview | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Oryctolagus cuniculus | increased HDL cholesterol after LCAT lecithin-cholesterol acyltransfer activity inhibits progression of atherosclerosis and induces cholesterol unloading in complex lesions in rabbits, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
New Zealand white rabbits | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | increased HDL cholesterol after LCAT lecithin-cholesterol acyltransfer activity inhibits progression of atherosclerosis and induces cholesterol unloading in complex lesions in rabbits, overview | Oryctolagus cuniculus | ? | - |
? | |
additional information | LCAT catalyzes the transacylation of a fatty acid at the sn-2 position of phosphatidylcholine preferentially to the free 3beta-hydroxyl group of cholesterol in HDL and to a lesser extent in LDL particles | Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lecithin:cholesterol acyltransferase | - |
Oryctolagus cuniculus |