Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | ApoA-I, required for activity, activation in inhibited by binding of haptoglobin | Homo sapiens | |
apolipoprotein E | ApoE, stimulates the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Haptoglobin | binds apolipoprotein A-I and E, via its Hpt beta-subunit, and impairs its stimulation of LCAT, mechanism, overview. The affinity of Hpt for ApoE is higher than that for ApoA-I. Hpt also impairs human hepatoblastoma-derived cell uptake of cholesterol from proteoliposomes containing ApoE or ApoA-I | Homo sapiens | |
additional information | interaction between Hpt and ApoE represents a mechanism by which inflammation affects atherosclerosis progression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | Homo sapiens | - |
cholesteryl ester + lysophosphatidylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin:cholesterol acyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | LCAT plays a major role in reverse cholesterol transport, RCT | Homo sapiens |