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Literature summary for 2.3.1.43 extracted from

  • Cigliano, L.; Pugliese, C.R.; Spagnuolo, M.S.; Palumbo, R.; Abrescia, P.
    Haptoglobin binds the antiatherogenic protein apolipoprotein E - impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (2009), FEBS J., 276, 6158-6171.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I ApoA-I, required for activity, activation in inhibited by binding of haptoglobin Homo sapiens
apolipoprotein E ApoE, stimulates the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Haptoglobin binds apolipoprotein A-I and E, via its Hpt beta-subunit, and impairs its stimulation of LCAT, mechanism, overview. The affinity of Hpt for ApoE is higher than that for ApoA-I. Hpt also impairs human hepatoblastoma-derived cell uptake of cholesterol from proteoliposomes containing ApoE or ApoA-I Homo sapiens
additional information interaction between Hpt and ApoE represents a mechanism by which inflammation affects atherosclerosis progression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens
-
cholesteryl ester + lysophosphatidylcholine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + cholesterol
-
Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
?

Synonyms

Synonyms Comment Organism
LCAT
-
Homo sapiens
lecithin:cholesterol acyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function LCAT plays a major role in reverse cholesterol transport, RCT Homo sapiens