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Literature summary for 2.3.1.43 extracted from

  • Reshetnyak, Y.; Tchedre, K.T.; Nair, M.P.; Pritchard, P.H.; Lacko, A.G.
    Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase (2006), J. Biomol. Struct. Dyn., 24, 75-82.
    View publication on PubMed
Search for more literature for 2.3.1.43

Protein Variants

Protein Variants Comment Organism
T123I naturally occuring mutation involved in the fish eye disease, conformational changes upon substrate binding is altered in mutant T123I compared to the wild-type enzyme, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is responsible for the cholesterol transport, controlling the flow of cholesterol from peripheral tissues to the liver ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung secretion to plasma Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dioleoyl-phosphatidyl choline + cholesterol
-
 Homo sapiens 1-oleoyl-phosphatidyl choline + cholesteryl oleate
-
 ?
HDL + cholesterol
-
 Homo sapiens ?
-
 ?
additional information the enzyme is responsible for the cholesterol transport, controlling the flow of cholesterol from peripheral tissues to the liver Homo sapiens ?
-
 ?
additional information comparison of conformational changes upon substrate binding of wild-type enzyme and mutant T123I, a naturally occuring mutation involved in the fish eye disease, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More Trp61 functions as a component of the interfacial recognition domain of the enzyme, comparison of conformational changes upon substrate binding of wild-type enzyme and mutant T123I, overview Homo sapiens

Synonyms

Synonyms Comment Organism
LCAT
-
 Homo sapiens
lecithin:cholesterol acyltransferase
-
 Homo sapiens