Protein Variants | Comment | Organism |
---|---|---|
T123I | naturally occuring mutation involved in the fish eye disease, conformational changes upon substrate binding is altered in mutant T123I compared to the wild-type enzyme, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is responsible for the cholesterol transport, controlling the flow of cholesterol from peripheral tissues to the liver | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | secretion to plasma | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dioleoyl-phosphatidyl choline + cholesterol | - |
Homo sapiens | 1-oleoyl-phosphatidyl choline + cholesteryl oleate | - |
? | |
HDL + cholesterol | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme is responsible for the cholesterol transport, controlling the flow of cholesterol from peripheral tissues to the liver | Homo sapiens | ? | - |
? | |
additional information | comparison of conformational changes upon substrate binding of wild-type enzyme and mutant T123I, a naturally occuring mutation involved in the fish eye disease, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | Trp61 functions as a component of the interfacial recognition domain of the enzyme, comparison of conformational changes upon substrate binding of wild-type enzyme and mutant T123I, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin:cholesterol acyltransferase | - |
Homo sapiens |