Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | required for transferase and phospholipase activity | Homo sapiens | |
apolipoprotein A-I | absolute requirement with phosphatidylcholine-cholesterol vesicles as a substrate | Homo sapiens | |
additional information | apo-A-II, apo-C-III and apo-D inhibit activation of enzyme by apo-A-1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-II | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000091 | - |
apolipoprotein-A-I | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
59000 | - |
sedimentation equilibrium ultracentrifugation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | 24% carbohydrate by weight, 13 mol of mannose, 30 mol of galactose, 17 mol of glucosamine and 13 mol of sialic acid per mol of enzyme protein | Homo sapiens |
Purification (Comment) | Organism |
---|---|
affinity chromatography using an anti-apolipoprotein D immunoglobulin-Sepharose column | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
0.01 | - |
in cholesterol-lecithin vesicles activated with apolipoprotein A1, at 37°C and pH 7.1 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | phospholipase activity | Homo sapiens | ? | - |
? | |
additional information | lecithin-cholesterol single bilayer vesicles as substrate | Homo sapiens | ? | - |
? | |
phosphatidylcholine + sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r |