Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | absolute requirement with phosphatidylcholine-cholesterol vesicles as a substrate | Homo sapiens | |
Apolipoprotein C-1 | cofactor activity, less effective than apo-A-1 | Homo sapiens | |
additional information | apo-A-II, apo-C-III and apo-D inhibit activation of enzyme by apo-A-1 | Homo sapiens |
General Stability | Organism |
---|---|
apo-A-1, albumin and lecithin-cholesterol vesicles stabilize | Homo sapiens |
glycerol stabilizes during storage at -20°C | Homo sapiens |
lability to freezing and thawing and to high ionic strength | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | at high concentration | Homo sapiens | |
dithiothreitol | at high concentration | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
59000 | - |
sedimentation equilibrium ultracentrifugation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + sterol | Homo sapiens | important in metabolism and structure of plasma lipoproteins | 1-acylglycerophosphocholine + sterol ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | 24% carbohydrate by weight, 13 mol of mannose, 30 mol of galactose, 17 mol of glucosamine and 13 mol of sialic acid per mol of enzyme protein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.7 | - |
in cholesterol-lecithin vesicles | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | long-chain primary alcohols can act as acyl acceptors | Homo sapiens | ? | - |
? | |
additional information | lecithin-cholesterol single bilayer vesicles as substrate | Homo sapiens | ? | - |
? | |
phosphatidylcholine + sterol | wide specificity for acyl acceptor: sterols with a beta-configuration at carbon-3 and trans fused A /B rings | Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r | |
phosphatidylcholine + sterol | cholesterol as substrate | Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r | |
phosphatidylcholine + sterol | acyl donor: high degree of specificity for phospholipids containing a basic nitrogen atom | Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r | |
phosphatidylcholine + sterol | important in metabolism and structure of plasma lipoproteins | Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
? |