Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae cells | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | - |
Trypanosoma brucei | 20015 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + glycerone phosphate | Trypanosoma brucei | - |
CoA + acylglycerone phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + glycerone phosphate | - |
Trypanosoma brucei | CoA + acylglycerone phosphate | - |
? | |
arachidonoyl-CoA + glycerone phosphate | less than 10% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + arachidonoylglycerone phosphate | - |
? | |
lauroyl-CoA + glycerone phosphate | less than 10% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + lauroylglycerone phosphate | - |
? | |
linoleoyl-CoA + glycerone phosphate | about 25% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + linoleoylglycerone phosphate | - |
? | |
myristoyl-CoA + glycerone phosphate | about 60% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + myristoylglycerone phosphate | - |
? | |
oleoyl-CoA + glycerone phosphate | about 35% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + oleoylglycerone phosphate | - |
? | |
palmitoleoyl-CoA + glycerone phosphate | about 60% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + palmitoleoylglycerone phosphate | - |
? | |
palmitoyl-CoA + glycerone phosphate | 100% activity. Palmitoyl-CoA is the preferred acyl-CoA donor | Trypanosoma brucei | CoA + palmitoylglycerone phosphate | - |
? | |
stearoyl-CoA + glycerone phosphate | about 20% activity compared to palmitoyl-CoA | Trypanosoma brucei | CoA + stearoylglycerone phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 137000, calculated from amino acid sequence | Trypanosoma brucei |
Synonyms | Comment | Organism |
---|---|---|
DAT | - |
Trypanosoma brucei |
DHAP acyltransferase | - |
Trypanosoma brucei |
DHAPAT | - |
Trypanosoma brucei |
dihydroxyacetonephosphate acyltransferase | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
metabolism | in Trypanosoma brucei procyclic forms the enzyme is the physiologically relevant initial acyltransferase producing ether lipid precursors | Trypanosoma brucei |
physiological function | the enzyme is important for survival during stationary phase and synthesis of ether lipids. In contrast, the enzyme is dispensable for normal growth | Trypanosoma brucei |