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Literature summary for 2.3.1.42 extracted from
- Purification of dihydroxyacetone phosphate acyltransferase from guinea pig liver peroxisomes (1993), Arch. Biochem. Biophys., 300, 88-97.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Phospholipid | activation, e.g. phosphatidylcholine, dilauroylphosphatidylcholine | Cavia porcellus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CoA | - |
Cavia porcellus | |
| coenzyme A | kinetics | Cavia porcellus | |
| N-ethylmaleimide | weak | Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.061 | 0.078 | dihydroxyacetone phosphate | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Cavia porcellus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 69000 | - |
x * 69000, SDS-PAGE | Cavia porcellus |
| 90000 | - |
gel filtration | Cavia porcellus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + dihydroxyacetone phosphate | Cavia porcellus | initiates glycerolipid, especially ether-linked glycerolipid, biosynthesis in higher eukaryotes | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, i.e. CHAPS, plus 0.15 M NaCl | Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.47 | - |
purified enzyme | Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + dihydroxyacetone phosphate | - |
Cavia porcellus | CoA + acyldihydroxyacetone phosphate | i.e. acylglycerone phosphate | ? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | - |
Cavia porcellus | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | initiates glycerolipid, especially ether-linked glycerolipid, biosynthesis in higher eukaryotes | Cavia porcellus | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 69000, SDS-PAGE | Cavia porcellus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cavia porcellus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.76 | - |
CoA | - |
Cavia porcellus | |
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Release 2023.1 (January 2023)
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