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Literature summary for 2.3.1.35 extracted from
- ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity (2002), Eur. J. Biochem., 269, 2052-2059.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Streptomyces clavuligerus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.6 | - |
alpha-N-acetyl-L-ornithine | - |
Streptomyces clavuligerus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
alpha2beta2, 2 * 19000 + 2 * 25000, SDS-PAGE | Streptomyces clavuligerus |
| 25000 | - |
alpha2beta2, 2 * 19000 + 2 * 25000, SDS-PAGE | Streptomyces clavuligerus |
| 83000 | - |
gel filtration | Streptomyces clavuligerus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N2-acetyl-L-ornithine + L-glutamate | Streptomyces clavuligerus | first step in arginine biosynthesis | L-ornithine + N-acetyl-L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces clavuligerus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces clavuligerus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.087 | - |
- |
Streptomyces clavuligerus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N2-acetyl-L-ornithine + L-glutamate | specific for L-glutamate | Streptomyces clavuligerus | L-ornithine + N-acetyl-L-glutamate | - |
? | |
| N2-acetyl-L-ornithine + L-glutamate | first step in arginine biosynthesis | Streptomyces clavuligerus | L-ornithine + N-acetyl-L-glutamate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotetramer | alpha2beta2, 2 * 19000 + 2 * 25000, SDS-PAGE | Streptomyces clavuligerus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Streptomyces clavuligerus |
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Release 2023.1 (January 2023)
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