Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.33 extracted from

  • Yamada, S.; Tanaka, Y.; Furuichi, M.
    Partial purification and characterization of histidine acetyltransferase in brain of Nile tilapia (Oreochromis niloticus) (1995), Biochim. Biophys. Acta, 1245, 239-247.
    View publication on PubMed
Search for more literature for 2.3.1.33

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol slightly inhibitory Oreochromis niloticus
Co2+
-
 Oreochromis niloticus
coenzyme A
-
 Oreochromis niloticus
Cu2+ complete inhibition Oreochromis niloticus
dithiothreitol
-
 Oreochromis niloticus
Hg2+ strong inhibition Oreochromis niloticus
hydroxylamine slightly inhibitory Oreochromis niloticus
additional information no inhibition by EDTA, Cd2+, Mg2+, Mn2+, Sr2+, Ca2+, Pb2+ Oreochromis niloticus
N-ethylmaleimide
-
 Oreochromis niloticus
N-ethylmorpholine-HCl buffer slightly inhibitory Oreochromis niloticus
Ni2+ strong inhibition Oreochromis niloticus
o-phenanthroline slightly inhibitory Oreochromis niloticus
p-chloromercuribenzoate strong inhibition Oreochromis niloticus
Tris-HCl buffer slightly inhibitory Oreochromis niloticus
Zn2+
-
 Oreochromis niloticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
 acetylcoenzyme A
-
 Oreochromis niloticus
0.45
-
 L-histidine
-
 Oreochromis niloticus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ stimulates Oreochromis niloticus
additional information no divalent metal ions required Oreochromis niloticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38500
-
 1 * 38500, SDS-PAGE Oreochromis niloticus
39000
-
 gel filtration Oreochromis niloticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-histidine Oreochromis niloticus
-
 CoA + N-acetyl-L-histidine
-
 ?

Organism

Organism UniProt Comment Textmining
Oreochromis niloticus
-
 Nile tilapia
-

Purification (Commentary)

Purification (Comment) Organism
partial Oreochromis niloticus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Oreochromis niloticus
-
lens
-
 Oreochromis niloticus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 tissue distribution Oreochromis niloticus
4.3
-
 partially purified enzyme Oreochromis niloticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 1-methyl-L-histidine 23% activity compared to that with L-histidine Oreochromis niloticus CoA + 1-methyl-N-acetyl-L-histidine
-
 ?
acetyl-CoA + 3-methyl-L-histidine 71% activity compared to that with L-histidine Oreochromis niloticus CoA + 3-methyl-N-acetyl-L-histidine
-
 ?
acetyl-CoA + L-histidine
-
 Oreochromis niloticus CoA + N-acetyl-L-histidine
-
 ?
acetyl-CoA + L-histidine strictly specific for the substrates Oreochromis niloticus CoA + N-acetyl-L-histidine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 38500, SDS-PAGE Oreochromis niloticus

Synonyms

Synonyms Comment Organism
HISAT
-
 Oreochromis niloticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Oreochromis niloticus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37 50 37°C: optimum, 50°C: less than 10% activity Oreochromis niloticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9.5 broad optimum, assay at pH 7.8 Oreochromis niloticus