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Literature summary for 2.3.1.32 extracted from
- Catalysis and substrate selection by histone/protein lysine acetyltransferases (2008), Curr. Opin. Struct. Biol., 18, 682-689.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| histone chaperone | Rtt109 associates with chaperone Vps75 (H3K9 and H3K23 acetylation in vivo) or Asf1 (H3K56 acetylation in vivo), stimulation of catalytic activity by chaperones, R55109 stimulates histone deposition by the chaperones, the complex of enzyme + chaperone alters substrate specificity, targets to specific loci, enhances acetyltransferase activity, restricts access of non-target proteins, and coordinates the multiple enzyme activities of the complex | Saccharomyces cerevisiae | |
| piccolo NuA4 complex | accessory proteins to support the function of Esa1, stimulating the catalytic activity of the enzyme | Saccharomyces cerevisiae | |
| SAGA complex | histone ubiquitin protease Ubp8 and histone acetyltransferase Gcn5 form a complex | Saccharomyces cerevisiae |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
acetyl-CoA | Rtt109 | Saccharomyces cerevisiae |  |
| 0.001 | - |
acetyl-CoA | Esa1 | Saccharomyces cerevisiae | |
| 0.001 | - |
acetyl-CoA | Rtt109 in complex with chaperone Vps75 | Saccharomyces cerevisiae | |
| 0.0025 | - |
acetyl-CoA | Gcn5 | Saccharomyces cerevisiae | |
| 0.0025 | - |
acetyl-CoA | Esa1 in piccolo NuA4-complex with Yng2 and Epl1 | Saccharomyces cerevisiae | |
| 0.04 | - |
acetyl-CoA | p300 | Saccharomyces cerevisiae | |
| 0.075 | - |
histone | Rtt109 in complex with chaperone Vps75 | Saccharomyces cerevisiae | |
| 0.083 | - |
histone | Rtt109 | Saccharomyces cerevisiae | |
| 0.16 | - |
histone | p300 | Saccharomyces cerevisiae | |
| 0.22 | - |
histone | Esa1 in piccolo NuA4-complex with Yng2 and Epl1 | Saccharomyces cerevisiae | |
| 0.49 | - |
histone | Gcn5 | Saccharomyces cerevisiae | |
| 1.4 | - |
histone | Esa1 | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | Homo sapiens | - |
CoA + acetyl-histone | - |
? | |
| acetyl-CoA + histone | Saccharomyces cerevisiae | - |
CoA + acetyl-histone | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces cerevisiae | - |
? | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | - |
Homo sapiens | CoA + acetyl-histone | - |
? | |
| acetyl-CoA + histone | - |
Saccharomyces cerevisiae | CoA + acetyl-histone | - |
? | |
| acetyl-CoA + histone peptide | - |
Saccharomyces cerevisiae | CoA + acetylated histone peptide | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Esa1 | histone target lysine H4K5, K8, K12, Htz1K14, minimum complex formation is necessary to exhibit full catalytic activity and for nucleosome recognition | Saccharomyces cerevisiae |
| Gcn5 | histone target lysine H3K9, 14, 36, constitutively active, can form a SAGA complex with histone ubiquitin protease Ubp8 | Saccharomyces cerevisiae |
| HAT | - |
Homo sapiens |
| HAT | - |
Saccharomyces cerevisiae |
| histone/protein lysine acetyltransferase | - |
Homo sapiens |
| histone/protein lysine acetyltransferase | - |
Saccharomyces cerevisiae |
| p/CAF | human histone target lysine H3K14, constitutively active | Homo sapiens |
| p300 | histone target lysine H2AK5, H2B, constitutively active, broad protein specificity | Saccharomyces cerevisiae |
| Rtt109 histone acetyltransferase | histone target lysine H3K56, K9, K23, complex formation necessary to exhibit full catalytic activity | Saccharomyces cerevisiae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0017 | - |
histone | Rtt109 | Saccharomyces cerevisiae | |
| 0.0019 | - |
histone | Esa1 | Saccharomyces cerevisiae | |
| 0.13 | - |
histone | Rtt109 in complex with chaperone Vps75 | Saccharomyces cerevisiae | |
| 1.6 | - |
histone | Esa1 in piccolo NuA4-complex | Saccharomyces cerevisiae | |
| 1.7 | - |
histone | Gcn5 | Saccharomyces cerevisiae | |
| 4.1 | - |
histone peptide | p300 | Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | transcriptional regulation via histone complex acetylation, possibility of longer chain acyl-CoA transfers is proposed for histone acetyltransferases | Homo sapiens |
| physiological function | transcriptional regulation via histone complex acetylation, possibility of longer chain acyl-CoA transfers is proposed for histone acetyltransferases | Saccharomyces cerevisiae |
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