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Literature summary for 2.3.1.31 extracted from

  • De Pascale, G.; Nazi, I.; Harrison, P.H.; Wright, G.D.
    beta-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents (2011), J. Antibiot., 64, 483-487.
    View publication on PubMed
Search for more literature for 2.3.1.31

Protein Variants

Protein Variants Comment Organism
S143A mutant does not show any acetyltransferase activity. Incubation of mutant HTAH with ebelactone A and inhibitor does not generate an enzyme-inhibitor adduct Haemophilus influenzae

Inhibitors

Inhibitors Comment Organism Structure
(3S,4S)-4-heptyl-3-methyloxetan-2-one
-
 Haemophilus influenzae
4-nonyloxetan-2-one
-
 Haemophilus influenzae
ebelactone A
-
 Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-homoserine
-
 Haemophilus influenzae CoA + O-acetyl-L-homoserine
-
 ?

Synonyms

Synonyms Comment Organism
homoserine transacetylase
-
 Haemophilus influenzae
HTA
-
 Haemophilus influenzae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Haemophilus influenzae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Haemophilus influenzae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 (3S,4S)-4-heptyl-3-methyloxetan-2-one pH 7.5, 37°C Haemophilus influenzae
0.084
-
 4-nonyloxetan-2-one pH 7.5, 37°C Haemophilus influenzae
0.203
-
 ebelactone A pH 7.5, 37°C Haemophilus influenzae