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Literature summary for 2.3.1.30 extracted from
- Structural and biochemical studies of serine acetyltransferase reveal why the parasite Entamoeba histolytica cannot form a cysteine synthase complex (2011), J. Biol. Chem., 286, 12533-12541.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of serine acetyltransferase (SAT) isoform 1 at 1.77 A, in complex with its substrate serine at 1.59 A and inhibitor Cys at 1.78 A resolution is reported | Entamoeba histolytica |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a mutant with a C terminus of EhSAT1 mutated to DWSI (4 amino acids changed) inhibits EhOASS efficiently | Entamoeba histolytica |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cysteine | competitive inhibitor of Ser | Entamoeba histolytica |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | Q9U8X2 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + L-serine | - |
Entamoeba histolytica | CoA + O-acetyl-L-serine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | - |
Entamoeba histolytica |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EhSAT1 | - |
Entamoeba histolytica |
| SAT isoform 1 | - |
Entamoeba histolytica |
| serine acetyltransferase | - |
Entamoeba histolytica |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Entamoeba histolytica |
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Release 2023.1 (January 2023)
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