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Literature summary for 2.3.1.251 extracted from

  • Cuesta-Seijo, J.A.; Neale, C.; Khan, M.A.; Moktar, J.; Tran, C.D.; Bishop, R.E.; Pomes, R.; Prive, G.G.
    PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler (2010), Structure, 18, 1210-1219.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of PagP in an SDS /2-methyl-2,4-pentanediol cosolvent system, to 1.4 A resolution. Phospholipid access occurs at the crenel present between strands F and G Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P37001
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PagP measures the palmitoyl group with an internal hydrocarbon ruler that is formed in the interior of the eightstranded antiparallel beta barrel. Phospholipid access occurs at the crenel present between strands F and G so the phospholipid head group can remain exposed to the cell exterior while the lipid acyl chain remains in a predominantly hydrophobic environment as it translocates to the protein interior Escherichia coli ?
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