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Literature summary for 2.3.1.251 extracted from

  • Thaipisuttikul, I.; Hittle, L.E.; Chandra, R.; Zangari, D.; Dixon, C.L.; Garrett, T.A.; Rasko, D.A.; Dasgupta, N.; Moskowitz, S.M.; Malmstroem, L.; Goodlett, D.R.; Miller, S.I.; Bishop, R.E.; Ernst, R.K.
    A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis-specific lipid A (2014), Mol. Microbiol., 91, 158-174.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.251

Activating Compound

Activating Compound Comment Organism Structure
Cyfos-7 phospholipase activity for PagP depends on presence of Triton X-100, dodecylmaltoside, or Cyfos-7 in decreasing order of specific activity Pseudomonas aeruginosa
dodecylmaltoside phospholipase activity for PagP depends on presence of Triton X-100, dodecylmaltoside, or Cyfos-7 in decreasing order of specific activity Pseudomonas aeruginosa
Triton X-100 phospholipase activity for PagP depends on presence of Triton X-100, dodecylmaltoside, or Cyfos-7 in decreasing order of specific activity. Triton X-100 participates as a substrate in the palmitoyltransferase reaction Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
D84A mutation does not alter protein function Pseudomonas aeruginosa
D84N mutation does not alter protein function Pseudomonas aeruginosa
D86A mutation does not alter protein function Pseudomonas aeruginosa
D86N mutation does not alter protein function Pseudomonas aeruginosa
H35F loss of catalytic activity Pseudomonas aeruginosa
H35N loss of catalytic activity Pseudomonas aeruginosa
H45F mutation does not alter protein function Pseudomonas aeruginosa
S85A mutation does not alter protein function Pseudomonas aeruginosa
S85G mutation does not alter protein function Pseudomonas aeruginosa
S87A mutation does not alter protein function Pseudomonas aeruginosa
S87G mutation does not alter protein function Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9I401
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Pseudomonas aeruginosa 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
-
 Pseudomonas aeruginosa 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
additional information enzyme from Pseudomonas aeruginosa transfers palmitates to the lipid A C-3' positions Pseudomonas aeruginosa ?
-
 ?

Synonyms

Synonyms Comment Organism
PA1343
-
 Pseudomonas aeruginosa