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Literature summary for 2.3.1.251 extracted from
- Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria (2000), EMBO J., 19, 5071-5080.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | outer membrane | Escherichia coli | 16020 | - |
| membrane | outer membrane | Salmonella enterica subsp. enterica serovar Typhimurium | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
2 * 20000, His-tagged protein, SDS-PAGE | Escherichia coli |
| 20000 | - |
2 * 20000, His-tagged protein, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
| 40000 | - |
His-tagged protein, treated with glutaraldehyde | Escherichia coli |
| 40000 | - |
His-tagged protein, treated with glutaraldehyde | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | Escherichia coli | - |
2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? |  |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | Salmonella enterica subsp. enterica serovar Typhimurium | - |
2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | - |
2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | Escherichia coli | - |
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | Salmonella enterica subsp. enterica serovar Typhimurium | - |
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | - |
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | Escherichia coli | - |
2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | Salmonella enterica subsp. enterica serovar Typhimurium | - |
2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | - |
2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| additional information | Escherichia coli | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | ? | - |
? | |
| additional information | Salmonella enterica subsp. enterica serovar Typhimurium | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | ? | - |
? | |
| additional information | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P37001 | - |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | Q8ZR06 | - |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | Q8ZR06 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication | Escherichia coli |
| 7.2 | - |
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication | Salmonella enterica subsp. enterica serovar Typhimurium |
| 9.7 | - |
substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Escherichia coli |
| 9.7 | - |
substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Salmonella enterica subsp. enterica serovar Typhimurium |
| 18.2 | - |
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication | Escherichia coli |
| 18.2 | - |
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication | Salmonella enterica subsp. enterica serovar Typhimurium |
| 23.3 | - |
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Escherichia coli |
| 23.3 | - |
substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Salmonella enterica subsp. enterica serovar Typhimurium |
| 29.6 | - |
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Escherichia coli |
| 29.6 | - |
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Escherichia coli | 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | - |
Escherichia coli | 2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 2-acyl-sn-glycero-3-phosphocholine + lipid X | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Escherichia coli | 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | - |
Escherichia coli | 2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | 2-acyl-sn-glycero-3-phosphocholine + lipid IVB | - |
? | |
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Escherichia coli | 2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A | - |
Escherichia coli | 2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Escherichia coli | 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A | - |
Escherichia coli | 2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A | - |
? | |
| 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A | - |
? | |
| additional information | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | Escherichia coli | ? | - |
? | |
| additional information | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| additional information | PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 20000, His-tagged protein, SDS-PAGE | Escherichia coli |
| dimer | 2 * 20000, His-tagged protein, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipid A palmitoyltransferase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| PagP | - |
Escherichia coli |
| PagP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
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