Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Drosophila melanogaster | 5789 | - |
endoplasmic reticulum membrane | - |
Mus musculus | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine | Drosophila melanogaster | the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a | CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine | - |
? | |
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine | Mus musculus | the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a expressed in L cells | CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene porc | - |
Mus musculus | - |
gene porc | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
L-929 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine | the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a | Drosophila melanogaster | CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine | - |
? | |
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine | the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a | Mus musculus | CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine | - |
? | |
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine | the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a expressed in L cells | Mus musculus | CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PORC | - |
Drosophila melanogaster |
PORC | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the family of membrane-bound O-acyltransferases (MBOAT), which transfer acyl groups, such as a palmitoyl group, to substrates | Drosophila melanogaster |
evolution | the enzyme belongs to the family of membrane-bound O-acyltransferases (MBOAT), which transfer acyl groups, such as a palmitoyl group, to substrates | Mus musculus |
malfunction | treatment with a chemical inhibitor of acyltransferases produces defective intracellular trafficking of Wingless | Drosophila melanogaster |
malfunction | Wnt-3a with defective acylation is not transferred from the endoplasmic reticulum | Mus musculus |
physiological function | enzyme overexpression in culture cells enhances the intracellular processing, for example, N-glycosylation, of Wingless, the Drosophila Wnt1 analogue | Drosophila melanogaster |
physiological function | porcupine is required for the acylation and secretion of Wnt-3a, porc-dependent acylation may regulate the processing and intracellular trafficking of Wnt, although acylation at Cys77 does not appear to be involved in these processes | Mus musculus |