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Literature summary for 2.3.1.250 extracted from

  • Kurayoshi, M.; Yamamoto, H.; Izumi, S.; Kikuchi, A.
    Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling (2007), Biochem. J., 402, 515-523.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt5a]-L-serine Homo sapiens
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 CoA + [Wnt5a]-O-(9Z)-hexadec-9-enoyl-L-serine
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H237
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt5a]-L-serine
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 Homo sapiens CoA + [Wnt5a]-O-(9Z)-hexadec-9-enoyl-L-serine
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 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt5a]-L-serine palmitoylation of Wnt-5a at Cys104 Homo sapiens CoA + [Wnt5a]-O-(9Z)-hexadec-9-enoyl-L-serine
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 ?

General Information

General Information Comment Organism
physiological function palmitoylation of Wnt-5a is important for the triggering of signalling at the cell surface level, the lipid-unmodified form of Wnt-5a cannot activate intracellular signal cascades. The palmitoylation is not essential for the secretion of Wnt-5a, but is necessary for its ability to suppress Wnt-3a-dependent T-cell factor transcriptional activity and to stimulate cell migration. Wnt-5a activates focal adhesion kinase and this activation also requires palmitoylation. Palmitoylation enables Wnt5a to induces the internalization of Fz5 and to promote cell migration by stimulating focal adhesion turnover Homo sapiens