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Literature summary for 2.3.1.234 extracted from

  • Wan, L.C.K.; Mao, D.Y.L.; Neculai, D.; Strecker, J.; Chiovitti, D.; Kurinov, I.; Poda, G.; Thevakumaran, N.; Yuan, F.; Szilard, R.K.; Lissina, E.; Nislow, C.; Caudy, A.A.; Durocher, D.; Sicheri, F.
    Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system (2013), Nucleic Acids Res., 41, 6332-6346.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
2.9 A crystal structure of isoform Qri7 reveals a simple homodimer arrangement that is supplanted by the heterodimerization of YgjD with protein YeaZ Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P36132 isoform Kae1
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Saccharomyces cerevisiae P43122 isoform Qri7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonylcarbamoyladenylate + adenine37 in tRNA
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Saccharomyces cerevisiae AMP + N6-L-threonylcarbamoyladenine37 in tRNA
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?
L-threonylcarbamoyladenylate + adenine37 in tRNA
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Saccharomyces cerevisiae AMP + N6-L-threonylcarbamoyladenine37 in tRNA isoform Qri7 and protein Sua5 are sufficient for N6-threonylcarbamoyladenosine biosynthesis in vitro ?

Synonyms

Synonyms Comment Organism
Kae1
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Saccharomyces cerevisiae
Qri7
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Saccharomyces cerevisiae
t(6)A synthase
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Saccharomyces cerevisiae
t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function isoform Kae1 is part of a larger macromolecular assembly called KEOPS with Kae1, Bud32, Cgi121, Gon7 and Pcc1 subunits. Kae1 provides a core essential function that other subunits within KEOPS have evolved to support. Isoform Qri7 complements isoform Kae1 function and complements the function of all subunits Saccharomyces cerevisiae
physiological function isoform Qri7 complements isoform Kae1 function and complements the function of all subunits of a larger macromolecular assembly called KEOPS with Kae1, Bud32, Cgi121, Gon7 and Pcc1 subunits, in growth, N6-threonylcarbamoyladenosine biosynthesis and, to a partial degree, telomeremaintenance. Qri7 alone is sufficient for N6-threonylcarbamoyladenosine biosynthesis with protein Sua5 in vitro Saccharomyces cerevisiae