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Literature summary for 2.3.1.23 extracted from

  • Chen, X.; Hyatt, B.A.; Mucenski, M.L.; Mason, R.J.; Shannon, J.M.
    Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells (2006), Proc. Natl. Acad. Sci. USA, 103, 11724-11729.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.23

Activating Compound

Activating Compound Comment Organism Structure
additional information glucocorticoids and fibroblast growth factor induce the enzyme Mus musculus
additional information glucocorticoids and fibroblast growth factor induce the enzyme Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells Mus musculus
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the enzyme contains a transmembrane domain Mus musculus 16020
-
membrane the enzyme contains a transmembrane domain Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
 x * 59000, recombinant enzyme, SDS-PAGE Mus musculus
63000
-
 x * 63000, recombinant enzyme, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is involved in dipalmitoylphosphatidylcholine synthesis ?
-
 ?
additional information Rattus norvegicus the enzyme is involved in dipalmitoylphosphatidylcholine synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3TFD2
-
-
Rattus norvegicus Q1HAQ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar type II cell
-
 Mus musculus
-
alveolar type II cell
-
 Rattus norvegicus
-
brain low expression level Mus musculus
-
brain low expression level Rattus norvegicus
-
intestine low expression level Rattus norvegicus
-
lung LPCAT is predominantly expressed in the lung Mus musculus
-
lung LPCAT is predominantly expressed in the lung, LPCAT expression in the developing and adult lung, overview Rattus norvegicus
-
additional information expression tissue distribution, overview Mus musculus
-
additional information expression tissue distribution, overview Rattus norvegicus
-
spleen
-
 Mus musculus
-
spleen low expression level Rattus norvegicus
-
stomach
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in dipalmitoylphosphatidylcholine synthesis Mus musculus ?
-
 ?
additional information the enzyme is involved in dipalmitoylphosphatidylcholine synthesis Rattus norvegicus ?
-
 ?
additional information substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis Mus musculus ?
-
 ?
additional information substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 63000, recombinant enzyme, SDS-PAGE Rattus norvegicus
? x * 59000, recombinant enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
LPCAT
-
 Mus musculus
LPCAT
-
 Rattus norvegicus
lysoPC acyltransferase
-
 Mus musculus
lysoPC acyltransferase
-
 Rattus norvegicus
lysophosphatidylcholine acyltransferase
-
 Mus musculus
lysophosphatidylcholine acyltransferase
-
 Rattus norvegicus