Literature summary for 2.3.1.221 extracted from

Chang, P.K.; Cary, J.W.; Yu, J.; Bhatnagar, D.; Cleveland, T.E.
The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis (1995), Mol. Gen. Genet., 248, 270-277.

Search for more literature for 2.3.1.221

Cloned(Commentary)

Cloned (Comment)	Organism
gene pksA, DNA and amino acid sequence determination and analysis	Aspergillus parasiticus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of strain SRRC 2043, a disruption mutant defective in the pksA locus	Aspergillus parasiticus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus parasiticus	Q12053	gene pksA	-
Aspergillus parasiticus SRRC 2043 / RHN1	Q12053	gene pksA	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mycelium	-	Aspergillus parasiticus	-

General Information

General Information	Comment	Organism
evolution	the pksA gene is located in the aflatoxin pathway gene cluster and is linked to the nor-1 gene, an aflatoxin pathway gene required for converting norsolorinic acid to averantin	Aspergillus parasiticus
malfunction	strain SRRC 2043 is a disruption mutant defective in the pksA locus. Disruption of pksA results in an inability to produce aflatoxin intermediates	Aspergillus parasiticus
metabolism	pksA is a polyketide synthase gene required for the early steps of aflatoxin biosynthesis	Aspergillus parasiticus

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Release 2023.1 (January 2023)