Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.22 extracted from

  • Bhat, B.G.; Wang, P.; Coleman, R.A.
    Sphingosine inhibits rat hepatic monoacylglycerol acyltransferase in Triton X-100 mixed micelles and isolated hepatocytes (1995), Biochemistry, 34, 11237-11244.
    View publication on PubMed
Search for more literature for 2.3.1.22

Activating Compound

Activating Compound Comment Organism Structure
sphingomyelin stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
phytosphingosine
-
 Rattus norvegicus
sphinganine
-
 Rattus norvegicus
sphingosine IC50 is 9 mol%, inhibits activity in Triton X-100 mixed micelles and isolated hepatocytes Rattus norvegicus
Stearylamine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-2-monoacylglycerol Rattus norvegicus the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway CoA + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-2-monoacylglycerol the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway Rattus norvegicus CoA + diacylglycerol
-
 ?