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Literature summary for 2.3.1.21 extracted from

  • Lin, X.; Shim, K.; Odle, J.
    Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine (2010), Am. J. Physiol. Regul. Integr. Comp. Physiol., 298, R1435-R1443.
    View publication on PubMed
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.079
-
 palmitoyl-CoA mitochondria isolated from newborn pig, pH 7.2, 30°C Sus scrofa
0.142
-
 palmitoyl-CoA mitochondria isolated from 24-h-old, fed pig, pH 7.2, 30°C Sus scrofa
0.293
-
 palmitoyl-CoA mitochondria isolated from 24-h-old, fasted pig, pH 7.2, 30°C Sus scrofa
0.461
-
 palmitoyl-CoA mitochondria isolated from adult pig, pH 7.2, 30°C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion of newborn, 24-h old, fed or fasted, and 5-months-old pigs Sus scrofa 5739
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-carnitine + palmitoyl-CoA
-
 Sus scrofa L-palmitoylcarnitine + CoA
-
 ?

Synonyms

Synonyms Comment Organism
CPT I
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00019
-
 mitochondria isolated from newborn pig, pH 7.2, 30°C Sus scrofa malonyl-CoA
0.00021
-
 mitochondria isolated from adult pig, pH 7.2, 30°C Sus scrofa malonyl-CoA
0.00026
-
 mitochondria isolated from 24-h-old, fed pig, pH 7.2, 30°C Sus scrofa malonyl-CoA
0.00053
-
 mitochondria isolated from 24-h-old, fasted pig, pH 7.2, 30°C Sus scrofa malonyl-CoA

General Information

General Information Comment Organism
physiological function measurements of enzyme activity in mitochondria isolated from newborn, 24-h-old, fed or fasted, and 5-months-old pigs. Acetate rather than ketone bodies is the predominant radiolabeled product, and its production increases twofold with increasing fatty acid oxidation during the first 24-h suckling period. The rate of acetogenesis is directly proportional to isoform CPT I activity. The high activity of CPT I in 24-h-suckling piglets is not attributable to an increase in CPT I gene expression, but rather to a large decrease in the sensitivity of CPT I to malonyl-CoA inhibition, which offsets a developmental decrease in affinity of CPT I for palmitoyl-CoA. Acetate is the primary product of hepatic mitochondrial beta-oxidation in Sus scrofa and regulation during early development is mediated primarily via kinetic modulation of isoform CPT I. Sus scrofa