Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
expressed in Pichia pastoris | Sus scrofa |
Protein Variants | Comment | Organism |
---|---|---|
D17E | pig protein: Glu in this position | Homo sapiens |
E17D | human protein: Asp in this position | Sus scrofa |
additional information | deletion of residues 1-18, and deletion of residues 1-28, human-pig chimeras | Sus scrofa |
additional information | pig-human chimeras | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
malonyl-CoA | - |
Homo sapiens | |
malonyl-CoA | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1976 | - |
L-carnitine | wild-type protein, mitochondrial preparation | Sus scrofa | |
0.6059 | - |
L-carnitine | E17D mutant protein, mitochondrial preparation | Sus scrofa | |
0.683 | - |
L-carnitine | wild-type protein, mitochondrial preparation | Homo sapiens | |
0.7695 | - |
L-carnitine | D17E mutant protein, mitochondrial preparation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00279 | - |
wild-type protein, mitochondrial preparation | Sus scrofa |
0.00416 | - |
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa |
0.00443 | - |
wild-type protein, mitochondrial preparation | Homo sapiens |
0.00449 | - |
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa |
0.00942 | - |
protein with deletion of residue 1-28, mitochondrial preparation | Sus scrofa |
0.00943 | - |
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens |
0.01059 | - |
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens |
0.01528 | - |
protein with deletion of residue 1-18, mitochondrial preparation | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-carnitine + palmitoyl-CoA | - |
Homo sapiens | L-palmitoylcarnitine + CoA | - |
? | |
L-carnitine + palmitoyl-CoA | - |
Sus scrofa | L-palmitoylcarnitine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase 1B | - |
Homo sapiens |
carnitine palmitoyltransferase 1B | - |
Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000096 | - |
wild-type protein, 1 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.000117 | - |
wild-type protein, 0.683 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.00019 | - |
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.000246 | - |
D17E mutant protein, 0.770 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.000279 | - |
D17E mutant protein, 1 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.000284 | - |
E17D mutant protein, 0.606 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.000297 | - |
E17D mutant protein, 1 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.000325 | - |
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
0.000359 | - |
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.000457 | - |
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.00055 | - |
wild-type protein, 0.198 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.000804 | - |
wild-type protein, 1 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.03556 | - |
protein with deletion of residue 1-18, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
0.03919 | - |
protein with deletion of residue 1-28, mitochondrial preparation | Sus scrofa | malonyl-CoA |