Literature summary for 2.3.1.20 extracted from

Inokoshi, J.; Kawamoto, K.; Takagi, Y.; Matsuhama, M.; Omura, S.; Tomoda, H.
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes (2009), J. Antibiot., 62, 51-54.

Search for more literature for 2.3.1.20

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
amidepsine A	-	Homo sapiens
amidepsine B	-	Homo sapiens
amidepsine C	-	Homo sapiens
amidepsine D	-	Homo sapiens
roselipin 1a	-	Homo sapiens
roselipin 1B	-	Homo sapiens
roselipin 2A	-	Homo sapiens
roselipin 2B	-	Homo sapiens
xanthohumol	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75907	-	-
Homo sapiens	Q96PD7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoyl-CoA + 1,2-dioleoyl-sn-glycerol	-	Homo sapiens	CoA + 1,2-dioleoyl-3-palmitoyl-sn-glycerol	-	?

Synonyms

Synonyms	Comment	Organism
acyl-CoA:diacylglycerol acyltransferase 1	-	Homo sapiens
acyl-CoA:diacylglycerol acyltransferase 2	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50 above 0.2 mM	Homo sapiens	roselipin 2B
additional information	-	IC50 above 0.2 mM	Homo sapiens	roselipin 2A
additional information	-	IC50 above 0.2 mM	Homo sapiens	roselipin 1B
additional information	-	IC50 above 0.2 mM	Homo sapiens	roselipin 1a
additional information	-	IC50 above 0.2 mM	Homo sapiens	amidepsine C
0.02	-	-	Homo sapiens	amidepsine D
0.03	-	-	Homo sapiens	roselipin 1a
0.03	-	-	Homo sapiens	amidepsine D
0.03	-	-	Homo sapiens	amidepsine B
0.04	-	-	Homo sapiens	xanthohumol
0.04	-	-	Homo sapiens	roselipin 1B
0.04	-	-	Homo sapiens	amidepsine A
0.045	-	-	Homo sapiens	roselipin 2A
0.05	-	-	Homo sapiens	roselipin 2B
0.06	-	-	Homo sapiens	amidepsine B
0.07	-	-	Homo sapiens	amidepsine A
0.2	-	-	Homo sapiens	amidepsine C

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Release 2023.1 (January 2023)