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Literature summary for 2.3.1.20 extracted from
- Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress (2006), Microbiology, 152, 2717-2725.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | tgs transcript levels are upregulated under various stress culture conditions | Mycobacterium tuberculosis |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is a possible target for antilatency drugs | Mycobacterium tuberculosis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene tgs1, expressionin Escherichia coli, the recombinant enzyme prefers C26 : 0-CoA for triglycerol accumulation | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | disruption of gene tgs1, i.e. Rv3130c, leads to drastically reduced triacylglycerol accumulation | Mycobacterium tuberculosis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mycobacterium tuberculosis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis | - |
strain ATCC 25618, gene tgs1 or Rv3130c | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diolein + hexacosanoyl-CoA | - |
Mycobacterium tuberculosis | ? | - |
? | |
| diolein + oleoyl-CoA | - |
Mycobacterium tuberculosis | triolein + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| diacylglycerol acyltransferase | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Mycobacterium tuberculosis |
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