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Literature summary for 2.3.1.191 extracted from

  • Eshghi, A.; Henderson, J.; Trent, M.S.; Picardeau, M.
    Leptospira interrogans lpxD homologue is required for thermal acclimatization and virulence (2015), Infect. Immun., 83, 4314-4321.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.191

Organism

Organism UniProt Comment Textmining
Leptospira interrogans
-
 serovar Manilae
-
Leptospira interrogans L495
-
 serovar Manilae
-

Synonyms

Synonyms Comment Organism
La0512
-
 Leptospira interrogans
LpxD1
-
 Leptospira interrogans

General Information

General Information Comment Organism
physiological function inactivation of isoform la0512/LpxD1, imparts sensitivity to the host physiological temperature (37°C) and renders the bacteria avirulent in an animal infection model. The LpxD1 mutant displays compromised outer membrane integrity at host physiological temperature, but only minor changes in the lipid A moiety compared to that found in the wild-type strain. An in trans complementation restores the phenotypes to a level comparable to that of the wild-type strain Leptospira interrogans